Pharmaniaga Metronidazole Special Precautions

Patients with severe hepatic disease metabolise metronidazole slowly, with resultant accumulation of metronidazole and its metabolites in the plasma. Accordingly, for such patients, doses below those usually recommended should be administered cautiously. Known or previously unrecognised candidiasis may present more prominent symptoms during therapy with metronidazole and requires treatment with a candidacidal agent. Caution is also advised in patients with active organism CNS disease including epilepsy and in patients with a history of blood dyscrasias.
Use in Children: When used for the treatment of anaerobic infections and amoebiasis, metronidazole has not demonstrated any paediatrics-specific problems that would limit its usefulness in children.
Use in Elderly: No information is available on the relationship of age to the effects of metronidazole in geriatric patients. However, elderly patients are more likely to have an age-related decrease in hepatic function, which may require an adjustment in dosage in patients receiving metronidazole.